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Adenosine receptors in the cardiovascular system
Author(s) -
Olsson Ray A.
Publication year - 1996
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/(sici)1098-2299(199611/12)39:3/4<301::aid-ddr9>3.0.co;2-v
Subject(s) - adenosine , adenosine receptor , vasodilation , medicine , pharmacology , angina , nitric oxide , purinergic signalling , cardiology , chemistry , neuroscience , receptor , agonist , biology , myocardial infarction
The remarkably comprehensive qualitative description of the cardiovascular actions of adenosine by Drury and Szent‐Györgyi [(1929): J Physiol 6:213–237] serves as a framework for current research on the cellular and molecular mechanisms of those actions. This article reviews eight areas in this field that have advanced significantly during the past 5 years: (1) the kinds of potassium channels coupled to the cardiomyocyte A 1 AR; (2) the mechanism of the anti‐adrenergic" action of adenosine; (3) the role of adenosine in angina pectoris; (4) the role of adenosine in ischemic preconditioning; (5) the occurrence of A 2 AR in ventricular myocytes; (6) evidence for A 1 ‐, A 2A ‐, A 2B ‐ and A 3 ARs in blood vessels; (7) the role of nitric oxide in adenosine‐initiated vasodilation; and (8) the effect of adenosine on microvascular permeability. In some areas, solid evidence has defined a particular mechanism; in others, the evidence is as yet incomplete. Drug Dev. Res. 39:301–307, 1996 © 1997 Wiley‐Liss, Inc.