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Adenosine (P1) receptor signalling
Author(s) -
Fredholm Bertil B.,
Arslan Giulia,
Kull Björn,
Kontny Ewa,
Svenningsson Per
Publication year - 1996
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/(sici)1098-2299(199611/12)39:3/4<262::aid-ddr5>3.0.co;2-p
Subject(s) - effector , signalling , adenosine , receptor , adenosine receptor , microbiology and biotechnology , signal transduction , g protein coupled receptor , signalling pathways , adenosine a2b receptor , chemistry , g protein , biology , biochemistry , agonist
The coupling of the four defined types of adenosine receptors to G proteins and the consequent activation of effector pathways is briefly summarized. It is pointed out that the G proteins are able to influence many types of cellular effector systems, and, in particular, that the α and the β,γ‐subunits may activate different signalling pathways that may either act synergistically or antagonistically in the cell. Because adenosine physiologically plays the role of a modulator, particular emphasis is placed on the interactions with parallel signalling pathways. Drug Dev. Res. 39:262–268, 1996. © 1997 Wiley‐Liss, Inc.