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Effects of purified oil of Anguilla japonica on human plasma lipids and immune function
Author(s) -
ChunWen Shan,
LiSha Sun,
SuQin Yang
Publication year - 1996
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/(sici)1098-2299(199610)39:2<135::aid-ddr4>3.0.co;2-q
Subject(s) - immune system , human plasma , function (biology) , chemistry , biochemistry , biology , chromatography , immunology , microbiology and biotechnology
In hyperlipidemia rats fed the purified oil of Anguilla japonica (POAJ, 127.7–510.8 mg/kg), we have shown that serum total cholesterol (TC), triglyceride (TG), and low density lipoprotein (LDL) decreasing percentages were 13.3–48.7, 9.5–25.2, and 5.1–62.2%, respectively, high density lipoprotein (HDL) incrasing percentage was 8.2–67.3%, and the POAJ (255.4–510.8 mg/kg) significantly reduced whole blood and plasma viscosity. The POAJ had marked increasing effect on some immunological indices, such as transferable function of T lymphocyte, in mice. In this paper, we show that the POAJ (1.8 g, 3 times a day, for 30 days) significantly lowered plasma lipids in 50 hyperlipidemia patients. The percentages of cases with marked efficiency for TC and TG decreasing were 92.0 and 88.0%, and those of cases with effectiveness (marked efficiency and efficiency) were 98.0 and 96.0%. In comparison with before‐treatment values, the decreasing percentages of TC, TG, LDL, and VLDL levels were 28.6, 54.3, 27.3, and 50.0%, and the increasing percentage of HDL was 70.0%, At the same time, the POAJ dramatically changed some immunological indices in which IgG and IgM levels increased by 25.0 and 36.8%, but C4 levels were lowered by 33.3%, respectively. Drug Dev. Res. 39:135–137. © 1997 Wiley‐Liss, Inc.