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α 1 Adrenoceptor subtypes: A synopsis of their pharmacology and molecular biology
Author(s) -
Hancock Arthur A.
Publication year - 1996
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/(sici)1098-2299(19960901)39:1<54::aid-ddr7>3.0.co;2-j
Subject(s) - molecular pharmacology , receptor , adrenergic receptor , biological activity , pharmacology , biology , computational biology , drug , genetics , in vitro
Pharmacological and molecular biological studies have revealed heterogeneity among α 1 adrenoceptor subtypes. Pharmacological agents used to characterize these sites often possess only moderate selectivity for a particular α 1 adrenoceptor or have effects on other adrenergic or nonadrenergic receptors. Cloning studies have identified distinct amino acid sequences for three subtypes of α 1 adrenoceptor, although the pharmacological characteristics of expressed receptors did not always coincide with expectations. As a result, controversial and alternate classification concepts have emerged that propose different numbers of α 1 adrenoceptors or different naming conventions. Recent advances with an increasing variety of more selective compounds have resulted in an emerging consensus that identifies three subtypes of α 1 adrenoceptor. The pharmacological and molecular biological studies that have contributed to or promoted resolution of these controversies are discussed in this review. Drug Dev. Res. 39:54–107. © 1997 Wiley‐Liss, Inc.