Premium
Effect of a depleter of cerebral monoamines on sleep patterns of a chelonian reptile
Author(s) -
AyalaGuerrero Fructuoso,
HuitrónReséndiz S.,
Mexicano G.
Publication year - 1996
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/(sici)1098-2299(19960901)39:1<115::aid-ddr9>3.0.co;2-i
Subject(s) - reserpine , wakefulness , vigilance (psychology) , electrophysiology , sleep (system call) , medicine , psychology , endocrinology , anesthesia , electroencephalography , biology , neuroscience , computer science , operating system
Effect of reserpine administration on sleep patterns was studied in chronically implanted adult turtles Gopherus berlandieri . Four states of vigilance that differed behaviorally and electrophysiologically were observed: active wakefulness, quiet wakefulness, quiet sleep, and active sleep. Animals spent 88 and 2.92% of the nychthemeral cycle in quiet and active sleep, respectively. The active sleep phases were of short duration reaching a mean of 22 ± 6 sec (mean ± SD) and showing an occurrence of 124 ± 33 (mean ± SD) throughout the 24‐h period. High voltage spikes were observed during quiet sleep at a frequency of 37 ± 9 spikes/min (mean ± SD). Reserpine elicited a significant reduction in total sleep time and in the occurrence of high voltage spikes ( P < 0.05). The number of active sleep episodes showed an important decrement throughout the nychthemeral cycle ( P < 0.01). Our data provide electrophysiological and pharmacological evidence to support the analogy of reptilian and mammalian sleep. Drug Dev. Res. 39:115–120 © 1997 Wiley‐Liss, Inc.