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Numbering of cloned P2 purinoceptors
Author(s) -
Burnstock Geoffrey,
King Brian F.
Publication year - 1996
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/(sici)1098-2299(199605)38:1<67::aid-ddr9>3.0.co;2-j
Subject(s) - purinergic receptor , receptor , biology , numbering , cloning (programming) , recombinant dna , genetics , gene , computer science , programming language
Over the last 3 years (March, 1993 to June, 1996), DNA sequences have been isolated for some 40 proteins that act as P2 purinoceptors. This explosion in receptor subtypes for nucleotide signalling and rate of advance (1 new receptor per month) have caused problems with the classification of these recombinant purinoceptors. At the request of the research community in this field, a “Purinoceptor Update Newsheet” was compiled at University College London with the view to monitoring and opening for general discussion new findings on P2 purinoceptor cloning and rapidly disseminating this information to investigators in this field. The present paper explains the system of numbering of the two families of receptor subtypes as proposed by Abbracchio and Burnstock [(1994): Pharmacol Ther 64:445–475] (P2X 1‐n and P2Y 1‐n purinoceptors, as extended families of ligand‐gated and G protein‐coupled receptors), and the order in which these subtypes appear in “Newsheet” tables. © 1996 Wiley‐Liss, Inc.