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Human DNA repair systems: An overview
Author(s) -
Yu Zhe,
Chen Jian,
Ford Barry N.,
Brackley Moyra E.,
Glickman Barry W.
Publication year - 1999
Publication title -
environmental and molecular mutagenesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1
H-Index - 87
eISSN - 1098-2280
pISSN - 0893-6692
DOI - 10.1002/(sici)1098-2280(1999)33:1<3::aid-em2>3.0.co;2-l
Subject(s) - dna repair , biology , human genome , gene , genetics , computational biology , genome , dna , human disease
DNA repair systems act to maintain genome integrity in the face of replication errors, environmental insults, and the cumulative effects of age. More than 70 human genes directly involved in the five major pathways of DNA repair have been described, including chromosomal location and cDNA sequence. However, a great deal of information as to the precise functions of these genes and their role in human health is still lacking. Hence, we summarize what is known about these genes and their contra part in bacterial, yeast, and rodent systems and discuss their involvement in human disease. While some associations are already well understood, it is clear that additional diseases will be found which are linked to DNA repair defects or deficiencies. Environ. Mol. Mutagen. 33:3–20, 1999 © 1999 Wiley‐Liss, Inc.