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Assessment of the genotoxic risk from laxative senna products
Author(s) -
Brusick David,
Mengs Ulrich
Publication year - 1997
Publication title -
environmental and molecular mutagenesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1
H-Index - 87
eISSN - 1098-2280
pISSN - 0893-6692
DOI - 10.1002/(sici)1098-2280(1997)29:1<1::aid-em1>3.0.co;2-j
Subject(s) - laxative , senna , traditional medicine , mutagen , genotoxicity , biology , toxicology , carcinogen , medicine , toxicity , genetics , constipation
Laxative senna products and several of their specific components have been submitted to a large number of genetic tests. While most studies gave negative responses, results from some of the studies suggest that components of senna products, particularly emodin and aloe‐emodin, have genotoxic activity. Assessment of the genotoxicity profile of these substances, in light of other data from animal and human metabolism or kinetic studies, human clinical trials and rodent carcinogenicity studies do not support concerns that senna laxatives pose a genotoxic risk to humans when consumed under prescribed use conditions. Environ. Mol. Mutagen. 29: 1–9, 1997 © 1997 Wiley‐Liss, Inc.