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Method for constructing confidently ordered linkage maps
Author(s) -
Broman Karl W.,
Weber James L.
Publication year - 1999
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/(sici)1098-2272(1999)16:4<337::aid-gepi1>3.0.co;2-t
Subject(s) - linkage (software) , recombination , chromosome , genetics , genetic linkage , biology , computational biology , evolutionary biology , computer science , gene
Abstract We describe a method for identifying, from a comprehensive genetic map, the most dense framework of confidently ordered markers. The approach uses the number of observed recombination events between each pair of markers, and finds the largest subset of markers for which adjacent loci are separated by at least one recombination. We illustrate the approach using a short region of chromosome 7p. Genet. Epidemiol. 16:337–343, 1999. © 1999 Wiley‐Liss, Inc.