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Using information from both parents when testing for association between marker and disease loci
Author(s) -
Whittaker J.C.,
Morris A.P.,
Curnow R.N.
Publication year - 1998
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/(sici)1098-2272(1998)15:2<193::aid-gepi7>3.0.co;2-7
Subject(s) - disequilibrium , transmission disequilibrium test , independence (probability theory) , allele , association test , genetics , biology , linkage disequilibrium , association (psychology) , genetic association , disease , transmission (telecommunications) , evolutionary biology , statistics , psychology , computer science , medicine , mathematics , haplotype , genotype , gene , single nucleotide polymorphism , telecommunications , psychotherapist , ophthalmology
Several extensions of the transmission/disequilibrium test (TDT) to multi‐allelic markers now exist. In some of these, however, separate tests must be performed on male and female parents because of the non‐independence of parental transmission patterns, reducing power, and complicating interpretation of the test results. Here we show that this non‐independence is asymptotically irrelevant when using the allelic TDT of Bickeböller and Clerget‐Darpoux [(1995) Genet Epidemiol 12:577–582], allowing the analysis of data from both parents simultaneously. Genet. Epidemiol. 15:193–200,1998. © 1998 Wiley‐Liss, Inc.