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A multivariate model for the analysis of sibship covariance structure using marker information and multiple quantitative traits
Author(s) -
Vogler George P.,
Tang Weihong,
Nelson Tracy L.,
Hofer Scott M.,
Grant Julia D.,
Tarantino Lisa M.,
Fernandez Jose R.
Publication year - 1997
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/(sici)1098-2272(1997)14:6<921::aid-gepi60>3.0.co;2-n
Subject(s) - quantitative trait locus , multivariate statistics , covariance , multivariate analysis , trait , statistics , biology , sample size determination , sample (material) , mathematics , genetics , computer science , gene , chemistry , chromatography , programming language
A model was developed to detect effects of quantitative trait loci (QTLs) in sibships from simulated nuclear family data using the full covariance structure of the data and analyzing all five quantitative traits simultaneously in a multivariate model. Evidence of the presence of loci was detected on chromosomes 4,8,9, and 10. The method provided stable results and is worth further exploration for its performance and optimal sample size requirements under realistic conditions. © 1997 Wiley‐Liss, Inc.