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Probabilities of identity‐by‐descent patterns in sibships when the parents are not genotyped
Author(s) -
Todorov A.A.,
Siegmund K.D.,
Gu C.,
Borecki I.B.,
Elston R.C.
Publication year - 1997
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/(sici)1098-2272(1997)14:6<909::aid-gepi58>3.0.co;2-q
Subject(s) - identity by descent , linkage (software) , identity (music) , nonparametric statistics , descent (aeronautics) , mathematics , statistics , computer science , genetics , biology , haplotype , geography , genotype , gene , physics , meteorology , acoustics
An assumption‐free algorithm has been applied to compute the probabilities of all possible identity‐by‐descent (IBD) configurations when the parents have not been genotyped. These probabilities can be used to determine the amount of information that a particular sibship will bring to a nonparametric linkage analysis. It is shown that the number of possible configurations can be extremely large even when the markers are closely spaced and are rather polymorphic. Further, it is not always possible to reduce this number to a manageable one simply by consideration of the relative probabilities of the configurations. © 1997 Wiley‐Liss, Inc.