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Sequential sib‐pair and association studies to detect genes in quantitative traits
Author(s) -
Savage Amanda,
Sun Fengzhu,
Crawford Dana C.,
Ashley Allison E.,
Yang Quanhe,
Sherman Stephanie L.
Publication year - 1997
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/(sici)1098-2272(1997)14:6<885::aid-gepi54>3.0.co;2-i
Subject(s) - genetics , quantitative trait locus , biology , gene , genetic association , association (psychology) , computational biology , genotype , single nucleotide polymorphism , psychology , psychotherapist
We applied sib‐pair and association methods to a GAW data set of nuclear families with quantitative traits. Our approaches included 1) preliminary statistical studies including correlations and linear regressions, 2) sib‐pair methods, and 3) association studies. We used a single data set to screen for linkage and association and, subsequently, additional data sets to confirm the preliminary results. Using this sequential approach, sib‐pair analysis provided evidence for the genes influencing Q1, Q2, and Q4. We correctly predicted MG1 for Q1, MG2 for Q2, and MG4 for Q4. We did not find any false positives using this approach. Association studies identified chromosomes 8 and 9 to be associated with Q4; however these are assumed to be false positives as no associations were modeled into the data. © 1997 Wiley‐Liss, Inc.