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Comparison of sib‐pair and variance‐components methods for genomic screening
Author(s) -
Pugh Elizabeth W.,
Jaquish Cashell E.,
Sorant Alexa J.M.,
Doetsch Jennifer P.,
BaileyWilson Joan E.,
Wilson Alexander F.
Publication year - 1997
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/(sici)1098-2272(1997)14:6<867::aid-gepi51>3.0.co;2-k
Subject(s) - variance components , statistics , biology , variance (accounting) , genetics , computational biology , evolutionary biology , mathematics , accounting , business
The statistical properties of sib‐pair and variance‐components linkage methods were compared using the nuclear family data from Problem 2. Overall, the power to detect linkage was not high for either method. The variance‐components method had better power for detection of linkage, particularly when covariates were included in the model. Type I error rates were similar to nominal error rates for both methods. © 1997 Wiley‐Liss, Inc.