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Logistic transmission modeling for the simulated data of GAW10 problem 2
Author(s) -
Neas Barbara R.,
Moser Kathy L.,
Harley John B.
Publication year - 1997
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/(sici)1098-2272(1997)14:6<857::aid-gepi49>3.0.co;2-m
Subject(s) - transmission disequilibrium test , linkage disequilibrium , locus (genetics) , pedigree chart , genetics , nonparametric statistics , biology , replicate , generalization , linkage (software) , chromosome , allele , computational biology , statistics , mathematics , haplotype , gene , mathematical analysis
A recently developed nonparametric method is a generalization of the transmission disequilibrium test across all alleles of a locus. This approach has been applied to Problem 2 of GAW10 and has been extended to explore the combined contribution of neighboring loci for chromosomes 1,5, and 8. When applied to the chromosome 5 data of the first replicate of the nuclear pedigrees from Problem 2 of GAW10, the data show that four of the 25 loci obtain a probability less than 0.05. However, when combined models composed of each potentially significant marker (p < 0.05) and its nearest neighbors are considered, the combined contributions of G14 and G15 are the most significant (p = 0.007). Consequently, the region near G14 and G15 is identified as the best candidate region in chromosome 5 for linkage to the common disease. © 1997 Wiley‐Liss, Inc.