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Multilocus quantitative trait analysis using the multipoint identity‐by‐descent method
Author(s) -
Lewis Cathryn M.,
Kort Edward N.
Publication year - 1997
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/(sici)1098-2272(1997)14:6<839::aid-gepi46>3.0.co;2-o
Subject(s) - quantitative trait locus , linkage (software) , identity by descent , biology , genetic linkage , genetics , trait , genetic analysis , evolutionary biology , allele , gene , computer science , haplotype , programming language
The multipoint identity‐by‐descent method (MIM) was extended to test for evidence of quantitative trait loci in two independent genetic regions. This method is a fast and feasible implementation of a multiple‐marker, two‐region linkage analysis for quantitative traits. It tests for significant evidence of quantitative trait loci (QTL) in neither, one or both genetic regions tested, and could be extended to an arbitrary number of independent genetic regions. A two‐stage analysis was used for the nuclear family data from GAW10. Initially, an analysis of the genomic search was carried out using single‐region MIM, with sets of six adjacent markers. Chromosomal regions that showed some evidence of linkage were identified and used in a two‐region MIM analysis. © 1997 Wiley‐Liss, Inc.