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The “possible triangle” test for extreme discordant sib pairs
Author(s) -
Kruse Rita,
Seuchter Susanne A.,
Baur Max P.,
Knapp Michael
Publication year - 1997
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/(sici)1098-2272(1997)14:6<833::aid-gepi45>3.0.co;2-o
Subject(s) - identity by descent , genetics , biology , statistics , mathematics , gene , allele , haplotype
For the analysis of quantitative traits in nuclear families, extreme discordant sib pairs proved to be more powerful than unselected sib pairs. Here, we present a test that makes use of selected pairs and, in addition, restricts the parameters of the identical‐by‐descent distribution analogously to the “possible triangle” for affected sib pairs. In the Problem 2A data, extreme discordant sib pairs are selected. The analysis allowed the detection of most simulated major genes. © 1997 Wiley‐ Liss, Inc.