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Genetic analysis of simulated oligogenic traits in nuclear and extended pedigrees: Summary of GAW10 contributions
Author(s) -
Wijsman Ellen M.,
Amos Christopher I.
Publication year - 1997
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/(sici)1098-2272(1997)14:6<719::aid-gepi28>3.0.co;2-s
Subject(s) - pedigree chart , multivariate statistics , multivariate analysis , genetic analysis , quantitative trait locus , phenotype , biology , genetics , statistics , mathematics , gene
Participants of GAW10 had available simulated data on phenotypic and marker data for 200 replicates of each of two different collections of pedigrees. The simulated phenotype was multivariate and oligogenic, and included a number of complexities. Participants took widely different approaches to analysis. We compare their results to identify analysis approaches and use of the data that had the greatest impact on the conclusions, accuracy of estimates, and power to identify genetic factors. © 1997 Wiley‐Liss, Inc.