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Model‐free age‐of‐onset methods applied to the linkage of bipolar disorder
Author(s) -
Zhu Xiaofeng,
Olson Jane M.,
Schnell Audrey H.,
Elston Robert C.
Publication year - 1997
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/(sici)1098-2272(1997)14:6<711::aid-gepi27>3.0.co;2-s
Subject(s) - pedigree chart , linkage (software) , concordance , trait , quantitative trait locus , age of onset , genetic linkage , regression , regression analysis , statistics , mathematics , disease , genetics , biology , medicine , computer science , gene , programming language
We performed Haseman‐Elston regression on a set of bipolar pedigrees using each of three dependent variables: a binary trait indicating disease concordance or discordance, a binary trait adjusted for age‐of‐onset, and the residuals from a survival analysis. The latter two methods, which both adjust for age‐of‐onset, gave smaller p‐values when previous analyses suggested linkage between disease and marker, but not when previous analyses were not suggestive of linkage. © 1997 Wiley‐Liss, Inc.