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Modeling age of onset and residual familial correlations for the linkage analysis of bipolar disorder
Author(s) -
Schnell Audrey H.,
Karunaratne P. Mahinda,
Witte John S.,
Dawson Deborah V.,
Elston Robert C.
Publication year - 1997
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/(sici)1098-2272(1997)14:6<675::aid-gepi21>3.0.co;2-m
Subject(s) - penetrance , linkage (software) , genetic linkage , sibling , locus (genetics) , bipolar disorder , genetics , residual , pedigree chart , nuclear family , lod score , correlation , statistics , biology , mathematics , psychology , chromosome , gene mapping , developmental psychology , algorithm , phenotype , gene , cognition , geometry , neuroscience , sociology , anthropology
We applied regressive modeling to the data described by Stine et al. [1995] and further explored the possible linkage of bipolar disorder to marker D18S41 on chromosome 18. We performed analyses to determine age‐ dependent penetrance functions that best fit the data and that allow for residual familial correlations. Specifically, we introduce here a simple method to allow for a sibling correlation that is not due to segregation at the linked locus, and then extend the results of Stine et al. [1995] by using the best fitting “regressive” model of this kind as input into a lod score linkage analysis. Although a formal segregation analysis was not attempted, a surprising finding was that, except for doubtful linkage to D18S41, there is little evidence for genetic transmission of bipolar disorder in these families. © 1997 Wiley‐Liss, Inc.