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GENEHUNTER: Application to analysis of bipolar pedigrees and some extensions
Author(s) -
Li Hongzhe,
Schaid Daniel J.
Publication year - 1997
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/(sici)1098-2272(1997)14:6<659::aid-gepi18>3.0.co;2-p
Subject(s) - pedigree chart , linkage (software) , set (abstract data type) , nonparametric statistics , computer science , data set , statistics , mathematics , artificial intelligence , genetics , programming language , biology , gene
A newly developed nonparametric multipoint linkage analysis (NPL) by Kruglyak et al. [1996] was applied to the data set from the Johns Hopkins Bipolar Study available through the GAW10 workshop. Our results from GENEHUNTER do not support the analyses of Stine et al. [1995]. Some possible extensions to incorporate unaffecteds are also discussed. © 1997 Wiley‐Liss, Inc.