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Bipolar disorder: Dominant or recessive on chromosome 5?
Author(s) -
Homer Jeanne P.,
Flodman Pamela L.,
Spence M. Anne
Publication year - 1997
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/(sici)1098-2272(1997)14:6<647::aid-gepi16>3.0.co;2-q
Subject(s) - locus (genetics) , genetics , bipolar disorder , biology , genetic linkage , gene , endocrinology , lithium (medication)
The presence of a susceptibility locus for bipolar disorder on chromosome 5p near the dopamine transporter gene has been suggested. We examined 52 bipolar families for linkage to two markers in this region under both dominant and recessive models of inheritance. The purpose of the analyses was to determine the mode of inheritance of this purported bipolar locus. We also ran sensitivity analyses to confirm the reliability of the linkage results. Our results suggest that a bipolar locus inherited in an autosomal dominant fashion may be linked to this region in a subset of families. © 1997 Wiley‐Liss, Inc.