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Analysis of bipolar disorder using affected relatives
Author(s) -
Davis Sean,
Sobel Eric,
Marinov Marin,
Weeks Daniel E.
Publication year - 1997
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/(sici)1098-2272(1997)14:6<605::aid-gepi9>3.0.co;2-y
Subject(s) - statistic , linkage (software) , markov chain monte carlo , lod score , cluster analysis , identity by descent , markov chain , genetics , monte carlo method , pedigree chart , statistics , chromosome , biology , allele , computer science , mathematics , gene mapping , gene , haplotype
We have analyzed the GAW10 data from several studies of bipolar affective disorder (BPAD) using the software packages SimIBD and SIMWALK2. SimIBD implements a simulation‐based affected‐pedigree‐member (APM) statistic, called SimAPM, as well as an APM‐like statistic, also called SimIBD, that measures identical‐by‐descent (IBD) sharing. SIMWALK2 uses Markov chain Monte Carlo techniques to compute several IBD‐based statistics on the degree of marker‐allele clustering among all affected relatives. We have found no strong evidence of linkage to either chromosome 5 or 18. However, we did find that several markers showed p‐values less than 0.01 and may deserve further study. © 1997 Wiley‐Liss, Inc.