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Investigation of the candidate genes ACTHR and Golf for bipolar illness by the transmission/disequilibrium test
Author(s) -
Bickeböller Heike,
Kistler Maria,
Scholz Michael
Publication year - 1997
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/(sici)1098-2272(1997)14:6<575::aid-gepi4>3.0.co;2-z
Subject(s) - transmission disequilibrium test , disequilibrium , linkage disequilibrium , transmission (telecommunications) , candidate gene , genetics , biology , linkage (software) , gene , haplotype , computer science , medicine , genotype , telecommunications , ophthalmology
Several versions of the transmission/disequilibrium test (TDT) were applied to the two candidate genes ACTHR and Golf for bipolar illness. Analyses were carried out separately for paternal and maternal transmission. Evidence for linkage and association was found for ACTHR for paternal transmission in support of a parent‐of‐origin effect. Possible evidence for segregation distortion was found for one of the two markers for Golf for maternal transmission. © 1997 Wiley‐Liss, Inc.