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Deriving components of genetic variance for multilocus models
Author(s) -
Tiwari Hemant K.,
Elston Robert C.
Publication year - 1997
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/(sici)1098-2272(1997)14:6<1131::aid-gepi95>3.0.co;2-h
Subject(s) - epistasis , variance components , inheritance (genetic algorithm) , variance (accounting) , linkage (software) , biology , locus (genetics) , genetic model , genetics , statistics , econometrics , mathematics , gene , accounting , business
Several authors have considered two‐locus models as a basis for the inheritance of complex diseases. The purpose of this paper is to give a simple general formulation to derive the additive, dominant, and epistatic effects, and hence the corresponding variance components, for any multilocus model. These variance components should be useful for investigating the power of model‐free linkage analysis to detect various modes of multilocus inheritance. © 1997 Wiley‐Liss, Inc.