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Analysis of two‐locus traits under heterogeneity for recessive versus dominant inheritance
Author(s) -
Leal Suzanne M.,
Ott Jurg
Publication year - 1997
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/(sici)1098-2272(1997)14:6<1097::aid-gepi89>3.0.co;2-c
Subject(s) - locus (genetics) , genetics , biology , allele , trait , quantitative trait locus , genetic heterogeneity , genetic model , inheritance (genetic algorithm) , genetic linkage , multifactorial inheritance , gene , phenotype , genotype , single nucleotide polymorphism , computer science , programming language
Complex traits have been modeled under various modes of two‐locus inheritance. One example of a two‐locus threshold model is the situation where an individual is susceptible to a disease trait if he or she carries three or more disease alleles. Under this model, if each locus is examined individually the inheritance appears recessive for some mating types and dominant for others. We developed a heterogeneity test, the Model‐heterogeneity test, where an admixture of dominant and recessive sibships can be present. The properties of the Model‐heterogeneity test were examined and compared to the Admixture test. The power of the Model‐heterogeneity test to detect linkage is comparable to that of the Admixture test. © 1997 Wiley‐Liss, Inc.