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Empirical affected‐sib‐pair statistics: Two simulation strategies
Author(s) -
Dina Christian,
Buzzi JeanClaude,
Demenais Florence,
Martinez Maria
Publication year - 1997
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/(sici)1098-2272(1997)14:6<1073::aid-gepi85>3.0.co;2-e
Subject(s) - loss of heterozygosity , statistics , biology , genetics , genotype , statistical hypothesis testing , mathematics , gene , allele
We compare two simulation procedures used to determine empirical distributions of three affected sib‐pair test‐statistics in family samples with missing parental marker information. P1 and P2 procedures differ according to whether affected sibs'genotypes are ignored (P1) or accounted for (P2) to generate the unknown parental genotypes. Overall, our results show that P2 procedure performs better than P1, particularly when marker heterozygosity is high (H = 75%) or when marker data from unaffected siblings are available with low marker heterozygosity (H = 50%). These results are similar for all affected sib‐pair tests. © 1997 Wiley‐Liss, Inc.