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Synergistic effect of two HLA heterodimers in the susceptibility to celiac disease in Tunisia
Author(s) -
Bouguerra F.,
Babron M.C.,
Eliaou J.F.,
Debbabi A.,
Clot J.,
Khaldi F.,
Greco L.,
ClergetDarpoux F.
Publication year - 1997
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/(sici)1098-2272(1997)14:4<413::aid-gepi6>3.0.co;2-3
Subject(s) - allele , genotype , human leukocyte antigen , disease , gene , genetics , biology , medicine , antigen
The DR and DQ HLA genotypes of 94 Tunisian children affected with celiac disease are analyzed so that we can gain a better understanding of the HLA component of this disease. All of them carry at least one of two specific heterodimers: a DQ heterodimer, encoded by DQA1*0501, DQB1*0201 and/or a DR heterodimer, encoded by the nonpolymorphic gene DRA and the DRB4 gene. Quantifying the relative penetrances of all susceptible genotypes gives evidence for a synergistic effect of these two heterodimers and for a dose effect of the alleles encoding the β chains of these two heterodimers. The DR3DR7 individuals have the greatest risk. They present the two kinds of heterodimers and carry two DQB1*0201 alleles. Celiac disease is the first HLA‐associated disease for which the at‐risk genotypes are so well delineated. Genet. Epidemiol. 14:413–422,1997. © 1997 Wiley‐Liss, Inc.