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Exact transmission‐disequilibrium tests with multiallelic markers
Author(s) -
Cleves Mario A.,
Olson Jane M.,
Jacobs Kevin B.
Publication year - 1997
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/(sici)1098-2272(1997)14:4<337::aid-gepi1>3.0.co;2-0
Subject(s) - linkage disequilibrium , disequilibrium , linkage (software) , markov chain , markov chain monte carlo , statistics , sampling (signal processing) , monte carlo method , genetics , transmission (telecommunications) , computer science , biology , mathematics , algorithm , haplotype , allele , medicine , filter (signal processing) , ophthalmology , computer vision , gene , telecommunications
The transmission‐disequilibrium (TD) test is a powerful method for detecting linkage between marker and disease loci in the presence of linkage disequilibrium. For multiallelic markers, we propose the use of exact tests, which are implemented using both an exact algorithm and Markov chain Monte Carlo simulation. Simulation studies show that exact tests improve both the small sample validity and the power of the TD method. We also compared the usual single‐affected‐offspring sampling scheme to one in which pairs of affected siblings are sampled. Affected‐sib‐pair sampling greatly increases the power of the TD method and will be most useful when a sample of affected sib pairs is available from prior linkage studies. Genet. Epidemiol. 14:337–347,1997. © 1997 Wiley‐Liss, Inc.