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Affected sibpair linkage tests for multiple linked susceptibility genes
Author(s) -
Farrall Martin
Publication year - 1997
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/(sici)1098-2272(1997)14:2<103::aid-gepi1>3.0.co;2-8
Subject(s) - linkage (software) , genetics , biology , gene , genetic linkage , computational biology
Genome‐wide searches for susceptibility genes using pairs of affected siblings are being undertaken to dissect out individual polygenes that contribute to human multi‐factorial diseases. Efficient identity‐by‐descent (IBD)‐based sibpair linkage tests are available that test individual markers or maps of linked markers for linkage to a single potative susceptibility gene. In order to assess the support for linkage to a second putative susceptibility gene that happens to map close to an established susceptibility gene, it is necessary to use a method that correctly allows for the IBD distortion that directly results from the linkage between the two genes. A maximum likelihood‐based, multilocus linkage test is proposed, which accounts for this interdependency and evaluates the support for an interaction between constituent susceptibility genes. The size and power of a test for a second linked susceptibility gene is investigated by simulation studies. Genet. Epidemiol. 14:103–115,1997. © 1997 Wiley‐Liss, Inc.