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Computation of multilocus prior probability of autozygosity for complex inbred pedigrees
Author(s) -
Guo SunWei
Publication year - 1997
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/(sici)1098-2272(1997)14:1<1::aid-gepi1>3.0.co;2-c
Subject(s) - pedigree chart , computer science , computation , genetics , biology , algorithm , gene
Abstract Homozygosity mapping is a very powerful method for mapping rare recessive diseases in humans. In many applications, it is often desirable to compute prior (or unconditional) multilocus probability of autozygosity for inbred pedigrees. This paper proposes a simple yet powerful method for computing the prior multilocus autozygosity probability for complex inbred pedigrees. The method has an added feature of providing explicit multilocus autozygosity probability in terms of recombination fractions, if desired. An example is presented to illustrate the method. Genet. Epidemiol. 14:1–15,1997. © 1997 Wiley‐Liss, Inc.