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On estimation of linkage test power
Author(s) -
Ginsburg E.Kh.,
Axenovich T.I.,
Goodman D.W.
Publication year - 1996
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/(sici)1098-2272(1996)13:4<355::aid-gepi4>3.0.co;2-3
Subject(s) - statistics , mathematics , recombination fraction , score test , linkage (software) , likelihood ratio test , maximum likelihood , fraction (chemistry) , power (physics) , physics , genetics , gene mapping , chemistry , organic chemistry , quantum mechanics , biology , chromosome , gene
Two methods of estimating linkage test power are proposed. The first method is based on the maximum likelihood (ML) estimate of the recombination fraction and is intended for use with a likelihood ratio test (LRT) in the form of a χ 2 or lod score. The power is estimated through a noncentral χ 2 distribution with a specially chosen noncentrality parameter. The second method uses the LRT constructed for a simple alternative hypothesis regarding the recombination fraction value. The approximate distribution of this test and a method of estimating its power is proposed. Using simulated pedigree data, the power estimates for these two methods were shown to be satisfactory. Comparisons among these two methods and the computer simulation approach of Boehnke [1986] are performed. © 1996 Wiley‐Liss, Inc.