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On planning of samples for linkage analysis: Two ways of a sample size reduction
Author(s) -
Ginsburg E.Kh.,
Axenovich T.I.
Publication year - 1996
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/(sici)1098-2272(1996)13:4<343::aid-gepi3>3.0.co;2-5
Subject(s) - linkage (software) , sample size determination , penetrance , sample (material) , reduction (mathematics) , statistics , type i and type ii errors , mathematics , genetic linkage , genetics , biology , phenotype , gene , chemistry , chromatography , geometry
Abstract The sample size required for a given type I and type II errors of linkage decision is determined by using the earlier proposed method of the linkage test power estimation [Ginsburg et al., 1996]. Dependence of the sample size on the heterozygotic genotype penetrance is investigated. Two approaches to sample size reduction are considered: the choice of marker gene and the special extension of analyzed pedigree structures. Their effects are quantitatively evaluated in some illustrative situations. It is shown that a practical reduction in sample size can be achieved only when the added part of a pedigree has a special set of phenotypic characteristics in its members. © 1996 Wiley‐Liss, Inc.