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Unbalanced translocation t(1;3)(p12–13;q11) in meningiomas as the unique feature of chordoid differentiation
Author(s) -
SteilenGimbel Heike,
Niedermayer Isolde,
Feiden Wolfgang,
Freiler Arno,
Steudel WolfIngo,
Zang Klaus D.,
Henn Wolfram
Publication year - 1999
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/(sici)1098-2264(199911)26:3<270::aid-gcc14>3.0.co;2-w
Subject(s) - chromosomal translocation , fluorescence in situ hybridization , biology , microdissection , chromosome , meningioma , karyotype , genetics , gene , pathology , medicine
Chordoid meningioma is a rare histological subtype of meningiomas. Cytogenetic analysis of three cases revealed the unique feature of an unbalanced translocation der(1)t(1;3)(p12–13;q11) that was ascertained by chromosome microdissection and reverse fluorescence in situ hybridization. As the t(1;3) has not been observed in other subtypes of meningioma, it may represent a specific cytogenetic marker of chordoid meningiomas. It is not yet clear whether a fusion gene or the combined loss of genes from chromosome arms 1p and 3p is the pathogenetically important outcome of the translocation. Genes Chromosomes Cancer 26:270–272, 1999. © 1999 Wiley‐Liss, Inc.