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Recurrent t(16;17)(q22;p13) in aneurysmal bone cysts
Author(s) -
Panoutsakopoulos Giorgos,
Pandis Nikos,
Kyriazoglou Ioannis,
Gustafson Pelle,
Mertens Fredrik,
Mandahl Nils
Publication year - 1999
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/(sici)1098-2264(199911)26:3<265::aid-gcc12>3.0.co;2-#
Subject(s) - aneurysmal bone cyst , medicine , surgery , lesion
Abstract Aneurysmal bone cyst (ABC) is a benign bone lesion for which no previous cytogenetic data exist. We describe the finding of clonal chromosome aberrations in three tumors; two had a t(16;17)(q22;p13) as the sole anomaly, and the third had a del(16)(q22) as the only change. These findings show that somatic mutations contribute to the development of ABC and furthermore indicate that bands 16q22 and 17p13 may harbor genes of importance in this process. Genes Chromosomes Cancer 26:265–266, 1999. © 1999 Wiley‐Liss, Inc.