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Recurrent DNA copy number losses associated with metastasis of larynx carcinoma
Author(s) -
Kujawski Maciej,
SarlomoRikala Maarit,
Gabriel Andrzej,
Szyfter Krzysztof,
Knuutila Sakari
Publication year - 1999
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/(sici)1098-2264(199911)26:3<253::aid-gcc10>3.0.co;2-a
Subject(s) - larynx , metastasis , medicine , primary tumor , basal cell , cancer , chromosome , carcinoma , head and neck , laryngeal neoplasm , oncology , pathology , head and neck cancer , cancer research , biology , gene , surgery , biochemistry
Squamous cell carcinomas of the head and neck show frequent and complex chromosome aberrations, but little is known about the changes that occur during the metastatic process. To compare the accumulation of changes in primary and metastatic tumors we analyzed 19 pairs of primary larynx cancer tumors and their metastases. The most frequent changes were found at 3p, 3q, 5p, 9, and 13. Losses at 13, 8p, and 9q were more frequent in metastases than in primary tumors. Genes Chromosomes Cancer 26:253–257, 1999. © 1999 Wiley‐Liss, Inc.