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Genomic alterations in distal bile duct carcinoma by comparative genomic hybridization and karyotype analysis
Author(s) -
Rijken Arjen M.,
Hu Jie,
Perlman Elizabeth J.,
Morsberger Laura A.,
Long Patricia,
Kern Scott E.,
Hruban Ralph H.,
Yeo Charles J.,
Griffin Constance A.
Publication year - 1999
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/(sici)1098-2264(199911)26:3<185::aid-gcc1>3.0.co;2-9
Subject(s) - comparative genomic hybridization , biology , cytogenetics , karyotype , bile duct cancer , pancreas , bile duct , pathology , pancreatic cancer , carcinoma , chromosome , cancer , cancer research , gene , genetics , medicine , biochemistry
We report genomic abnormalities identified in 14 human primary common bile duct carcinomas analyzed by cytogenetics or comparative genomic hybridization, or both. Combining the results of the two methods of analysis, 11 chromosomal arms were observed to be gained in whole or in part, and 9 chromosomal arms were lost in whole or in part in at least four tumors each. The most frequently lost chromosomal regions were, in decreasing order: 18q (eight tumors); 6q and 10p (seven tumors each); 8p, 12q, and 17p (six tumors each); and 7q, 12p, and 22q (four tumors each). The most frequently gained regions were 8q and 20q (six tumors each); 12p, 17q, and Xp (five tumors each); and 2q, 6p, 7p, 11q, 13q, and 19q (four tumors each). These results are similar to those we have previously reported in pancreatic cancer and suggest that carcinomas of the common bile duct and pancreas share a number of genetic changes. Genes Chromosomes Cancer 26:185–191, 1999. © 1999 Wiley‐Liss, Inc.