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Amplification of the 11q23 region in acute myeloid leukemia
Author(s) -
AvetLoiseau Hervé,
Godon Catherine,
Li JianYong,
Daviet Axelle,
Mellerin MariePaule,
Talmant Pascaline,
Harousseau JeanLuc,
Bataille Régis
Publication year - 1999
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/(sici)1098-2264(199910)26:2<166::aid-gcc9>3.0.co;2-p
Subject(s) - myeloid leukemia , medicine , leukemia , cancer research
Cytogenetic abnormalities involving the 11q23 region are found in both acute lymphoblastic leukemia (ALL) and myeloid leukemia (AML). Molecular consequences of 11q23 translocations are the formation of chimeric genes, all of them involving the MLL (mixed‐lineage leukemia) gene. To evaluate the usefulness of fluorescence in situ hybridization (FISH) in detecting MLL rearrangements in AML, we analyzed 181 patients with an MLL ‐specific probe. Among them, we detected three patients with multiple FISH signals, reflecting genomic amplification of this chromosomal region. Extra copies of MLL have been reported previously in four patients, but did not correspond to a true gene amplification. For the first time, we describe genomic amplification of the 11q23 region (up to more than 50 copies) in AML patients. This genomic amplification could affect MLL , but other genes in the vicinity could also be the primary target. Genes Chromosomes Cancer 26:166–170, 1999. © 1999 Wiley‐Liss, Inc.