Premium
Sublocalization of putative tumor suppressor gene loci on chromosome arm 14q in neuroblastoma
Author(s) -
Theobald Marco,
Christiansen Holger,
Schmidt Anke,
Melekian Badrig,
Wolkewitz Nicole,
Christiansen Nina M.,
Brinkschmidt Christian,
Berthold Frank,
Lampert Fritz
Publication year - 1999
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/(sici)1098-2264(199909)26:1<40::aid-gcc6>3.0.co;2-w
Subject(s) - suppressor , neuroblastoma , long arm , gene , biology , genetics , chromosome , tumor suppressor gene , cancer research , carcinogenesis , cell culture
RFLP and microsatellite analysis with 23 polymorphic markers spanning the entire long arm of chromosome 14 in 108 neuroblastomas showed allelic loss in 19 out of 107 (18%) informative tumors, placing 14q among the most frequently affected chromosomal regions in neuroblastoma. One minimal deletion region could be sublocalized in 17 of 19 cases between markers D14S1 and D14S16 , and a second one between markers D14S17 and D14S23 in band 14q32. Furthermore, breakpoints in bands 14q23 and 14q12 were detected. These results suggest the presence of at least two putative tumor suppressor gene loci on chromosome 14. Survival analyses revealed no prognostic impact of allelic loss of 14q in neuroblastoma. Genes Chromosomes Cancer 26:40–46, 1999. © 1999 Wiley‐Liss, Inc.