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High‐resolution deletion mapping of chromosome arm 1p in pancreatic cancer identifies a major consensus region at 1p35
Author(s) -
Hilgers Werner,
Tang David J.,
Sugar Avrahom Y.,
Shekher Manu C.,
Hruban Ralph H.,
Kern Scott E.
Publication year - 1999
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/(sici)1098-2264(199904)24:4<351::aid-gcc9>3.0.co;2-y
Subject(s) - loss of heterozygosity , breakpoint , biology , pancreatic cancer , deletion mapping , chromosome , cancer research , gene , tumor suppressor gene , cancer , genetics , carcinogenesis , allele
Chromosomal arm 1p has long been suspected, on the basis of loss of heterozygosity (LOH) and other data, to harbor a tumor suppressor gene important in pancreatic carcinomas and other tumors. We constructed a high‐resolution map of LOH at 1p in a panel of pancreatic adenocarcinomas. Using 44 markers, we identified LOH on 1p in 49% of 43 cancers. Breakpoints in 1p were identified in 15 of the carcinomas and could be used to ascertain consensus patterns. We found a major consensus region of LOH at 1p35 between loci D1S233 and D1S247. This region participates in the majority of LOH events on 1p in pancreatic cancer. These data provide a roadmap for further regional mapping, homozygous deletion searches, comparison to LOH patterns seen in other tumor types, and prioritization of studies using candidate genes. Genes Chromosomes Cancer 24:351–355, 1999. © 1999 Wiley‐Liss, Inc.