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Jumping translocation at 11q23 with MLL gene rearrangement and interstitial telomeric sequences
Author(s) -
Cuthbert Gavin,
McCullough Simon,
Finney Roger,
Breese Gareth,
Bown Nick
Publication year - 1999
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/(sici)1098-2264(199904)24:4<295::aid-gcc1>3.0.co;2-8
Subject(s) - chromosomal translocation , breakpoint , biology , fluorescence in situ hybridization , myeloid leukemia , cytogenetics , gene , genetics , gene rearrangement , microbiology and biotechnology , chromosomal rearrangement , karyotype , gene cluster , chromosome , cancer research
We report a case of acute myeloid leukemia (AML) M5a showing a jumping translocation with a breakpoint at 11q23. Fluorescence in situ hybridization (FISH) demonstrated triplication of the MLL gene and the presence of interstitial telomeric sequences, supporting the role of repetitive sequences in the mechanism of jumping translocations. Southern blot analysis of the MLL breakpoint cluster region showed the presence of an MLL gene rearrangement. Jumping translocation with MLL gene rearrangement is a previously unreported phenomenon in leukemia cytogenetics. Genes Chromosomes Cancer 24:295–298, 1999. © 1999 Wiley‐Liss, Inc.