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Comparative genomic hybridization reveals a recurrent pattern of chromosomal aberrations in severe dysplasia/carcinoma in situ of the cervix and in advanced‐stage cervical carcinoma
Author(s) -
Kirchhoff Maria,
Rose Hanne,
Petersen Bodil Laub,
Maahr Jan,
Gerdes Tommy,
Lundsteen Claes,
Bryndorf Thue,
KrygerBaggesen Niels,
Christensen Lise,
Aage Engelholm Svend,
Philip John
Publication year - 1999
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/(sici)1098-2264(199902)24:2<144::aid-gcc7>3.0.co;2-9
Subject(s) - comparative genomic hybridization , carcinoma in situ , cervix , dysplasia , biology , chromosome , stage (stratigraphy) , pathology , carcinoma , x chromosome , cancer , cervical cancer , medicine , gene , genetics , paleontology
We analyzed 17 cases of dysplasia/carcinoma in situ (CIS) of the cervix and 29 advanced‐stage cervical squamous cell carcinomas by comparative genomic hybridization (CGH). A comparable recurrent pattern of aberrations was detected in both preinvasive and invasive cases, although the total number of aberrations was much higher in the latter category. The most consistent chromosomal gain was mapped to chromosome arm 3q in 35% of preinvasive cases and in 72% of invasive cases. Chromosome aberrations were detected in 13/17 preinvasive cases with a total of 61 involved chromosome arms. In the invasive cases, frequent gains also occurred on 1q (45%), 8q (41%), 15q (41%), 5p (34%), and Xq (34%), and frequent losses were mapped to chromosome arms 3p (52%), 11q (48%), 13q (38%), 6q (38%), and 4p (34%). A recurrent pattern of aberrations has not previously been described in preinvasive lesions of the cervix. Our finding is surprising considering that only few preinvasive lesions are expected to progress to invasive cancer. Genes Chromosomes Cancer 24:144–150, 1999. © 1999 Wiley‐Liss, Inc.