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der(16)t(1;16)/der(1;16) in breast cancer detected by fluorescence in situ hybridization is an indicator of better patient prognosis
Author(s) -
Tsuda Hitoshi,
Takarabe Teruko,
Fukutomi Takashi,
Hirohashi Setsuo
Publication year - 1999
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/(sici)1098-2264(199901)24:1<72::aid-gcc10>3.0.co;2-m
Subject(s) - breast cancer , ductal carcinoma , medicine , cancer , oncology , fluorescence in situ hybridization , metastasis , pathology , biology , biochemistry , chromosome , gene
By two‐color fluorescence in situ hybridization (FISH), der(16)t(1;16) or der(1;16) was frequently detected in low‐grade papillary carcinoma but not in benign intraductal papilloma of the breast. In order to clarify the incidence and clinicopathological significance of der(16)t(1;16)/der(1;16) in common breast cancers, der(16)t(1;16)/der(1;16) was examined by two‐color FISH in breast cancers resected from 51 patients by using DNA probes for 16cen, 16q11.2, and 1q12 labeled with biotin or digoxigenin. der(16)t(1;16)/der(1;16) was clonally detected in 16 cancers (31%), being more frequent in ductal carcinomas of lower grade and invasive lobular carcinoma than in high‐grade invasive ductal carcinoma ( P < 0.001). der(16)t(1;16)/der(1;16) was also correlated with a higher amount of hormone receptors in the tumor ( P < 0.05). Disease‐free and overall survival rates of the patient group with der(16)t(1;16)/der(1;16)‐positive cancer were higher (88% and 94%) than those of the group with der(16)t(1;16)/der(1;16)‐negative cancer (39% and 68%) ( P < 0.05). Among the 16 patients with lymph node metastasis who received one of two similar forms of postsurgical adjuvant chemo‐endocrine therapy, the prognosis of those with der(16)t(1;16)/der(1;16)‐positive cancer was better than that of those with der(16)t(1;16)/der(1;16)‐negative cancer ( P < 0.05). der(16)t(1;16)/der(1;16) detected by FISH is considered helpful in identifying patients with a better prognosis and for stratification of patients in randomized clinical trials of adjuvant chemo‐endocrine therapies. Genes Chromosomes Cancer 24:72–77, 1999. © 1999 Wiley‐Liss, Inc.