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Chromosome band 1q21 is recurrently gained in desmoid tumors
Author(s) -
Larramendy Marcelo L.,
Virolainen Martti,
Tukiainen Erkki,
Elomaa Inkeri,
Knuutila Sakari
Publication year - 1998
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/(sici)1098-2264(199810)23:2<183::aid-gcc12>3.0.co;2-p
Subject(s) - comparative genomic hybridization , biology , chromosome , genetics , dna sequencing , dna , gene
DNA sequence copy number changes were studied by comparative genomic hybridization (CGH) in 28 desmoid tumors. Changes were detected in 12 tumors (43%) with a mean of 1.4 changes per sample (range: 1 to 7). Out of 12 tumors associated with pregnancy or Gardner's syndrome, only two displayed changes. The minimal common regions of the most frequent gains were 1q21 (39%), chromosome 20 (32%), and 9p12 (21%). No high‐level amplifications were detected. Losses of DNA sequences were two times less frequent than gains and the minimal common regions of the most frequent losses were 6q16–q21 (14%), 5q14 (11%), and 13q21–q31 (11%). Genes Chromosomes Cancer 23:183–186, 1998. © 1998 Wiley‐Liss, Inc.