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Deregulated expression of the TAL1 gene by t(1;5)(p32;q31) in patient with T‐cell acute lymphoblastic leukemia
Author(s) -
François Sylvie,
Delabesse Eric,
Baranger Laurence,
Dautel Marie,
Foussard Charles,
Boasson Marc,
Blanchet Odile,
Bernard Olivier,
Macintyre Elizabeth A.,
Ifrah Norbert
Publication year - 1998
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/(sici)1098-2264(199809)23:1<36::aid-gcc6>3.0.co;2-7
Subject(s) - lymphoblastic leukemia , leukemia , medicine , cancer research , microbiology and biotechnology , biology
TAL1 gene deregulation is frequent in T‐cell acute lymphoblastic leukemia (T‐ALL) and can result from translocations involving 1p32 or, more frequently, from a cytogenetically undetectable interstitial deletion of chromosome 1. This study presents a case of T‐ALL with a t(1;5)(p32;q31) involving TAL1 , in which the breakpoint occurs approximately 10 kbp 5′ to the gene and leads to transcriptional activation and synthesis of a TAL1 protein, and extends the spectrum of recognized TAL1 gene translocations associated with T‐ALL. Genes Chromosomes Cancer 23:36–43, 1998. © 1998 Wiley‐Liss, Inc.