Premium
A new case of translocation t(6;11)(q21;q23) in a therapy‐related acute myeloid leukemia resulting in an MLL–AF6q21 fusion
Author(s) -
Bernard Olivier A.,
Hillion Josette,
Le Coniat Maryvonne,
Berger Roland
Publication year - 1998
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/(sici)1098-2264(199807)22:3<221::aid-gcc7>3.0.co;2-y
Subject(s) - chromosomal translocation , breakpoint , myeloid leukemia , leukemia , fusion gene , acute myeloblastic leukemia , cancer research , biology , gene , medicine , genetics
A new case of translocation t(6;11)(q21;q23) in a patient with therapy‐related acute myeloblastic leukemia is reported. The translocation results in fusion of the MLL and AF6q21 genes. The breakpoint with AF6q21 is located within the sequences encoding the AF6q21 fork head motif. The similar location of the localization of the chromosome 6 breakpoints in the present case and in the first case reported suggests their nonrandom localization. In addition, treatment for Hodgkin's disease prior to leukemia in both t(6;11)(q21;q23) cases suggests an association of this translocation with therapy‐related leukemias, as reported for the recently described t(11;16)(q23;p13.3). Genes Chromosomes Cancer 22:221–224, 1998. © 1998 Wiley‐Liss, Inc.