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Chromosome region 8p11‐p21: Refined mapping and molecular alterations in breast cancer
Author(s) -
Adélaïde José,
Chaffanet Max,
Imbert Alexandra,
Allione Florence,
Geneix Jeanine,
Popovici Cornel,
van Alewijk Dirk,
Trapman Jan,
Zeillinger Robert,
BørresenDale AnneLise,
Lidereau Rosette,
Birnbaum Daniel,
Pébusque MarieJosèphe
Publication year - 1998
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/(sici)1098-2264(199807)22:3<186::aid-gcc4>3.0.co;2-s
Subject(s) - breast cancer , biology , chromosome , genetics , cancer research , computational biology , cancer , oncology , medicine , gene
Several genes, most of them unknown, of the short arm of chromosome 8 are involved in malignant diseases. Numerous studies have implicated a portion of the 8p11‐p21 region as the location of one or more tumor suppressor genes involved in a variety of human cancers, including breast cancer. We and others have reported linkage analyses suggesting the presence of a putative breast cancer susceptibility gene. Furthermore, several oncogenes of the 8p11‐p12 region are involved in reciprocal translocations in myeloproliferative and myelodysplastic disorders and in amplification in breast cancer. To facilitate the analysis of the 8p11‐p21 region and the cloning of candidate oncogenes and tumor suppressor genes, a high‐resolution physical and transcriptional map was established with 39 yeast artificial chromosomes and 94 markers, including so‐called sequence‐tagged sites and expressed sequence‐tagged sites derived from either known genes or expressed sequence tags corresponding to unidentified transcripts. In addition, four novel transcripts were identified and localized precisely within the map. This transcription map provides a detailed description of gene order for the 8p11‐p21 region and will be helpful in the identification of candidate genes for diseases. From this basis, we refined the mapping of two types of molecular alterations that occur at 8p11‐p21 in sporadic breast cancers, i.e., amplification and deletion. Genes Chromosomes Cancer 22:186–199, 1998. © 1998 Wiley‐Liss, Inc.