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Gain of 3q and deletion of 11q22 are frequent aberrations in mantle cell lymphoma
Author(s) -
Monni Outi,
Oin Riikka,
Elonen Erkki,
Franssila Kaarle,
Teerenhovi Lasse,
Joensuu Heikki,
Knuutila Sakari
Publication year - 1998
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/(sici)1098-2264(199804)21:4<298::aid-gcc3>3.0.co;2-u
Subject(s) - blastoid , mantle cell lymphoma , lymphoma , oncogene , comparative genomic hybridization , suppressor , biology , carcinogenesis , cancer research , tumor suppressor gene , gene , genetics , cell cycle , chromosome , immunology
We used comparative genomic hybridization (CGH) to screen for DNA copy number changes in 34 specimens from 27 cases of mantle cell lymphoma (MCL). The most common gains were detected at 3q (52%), 8q (30%), and 15q (26%), whereas the most frequent losses involved 13q (41%), 1p (33%), 6q (30%), 9p (30%), and 11q (30%). The gain of 3q, with a minimal common region at 3q26.1‐27, appeared in more than half of the lymphomas, suggesting the location of an important oncogene here. A common deleted region at 11q22 was found in one‐third of the patients, which suggests that this region may harbor a tumor suppressor gene important in the tumorigenesis of MCL. The mean number of changes was higher in more aggressive blastoid variants of MCL than in lymphomas with typical morphology. Our results show that the chromosomal regions affected in MCL are highly consistent and are different from those seen in other types of non‐Hodgkin's lymphoma. Genes Chromosomes Cancer 21:298–307, 1998. © 1998 Wiley‐Liss, Inc.