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Cytogenetic and molecular analysis of cellular atypical mesoblastic nephroma
Author(s) -
Speleman Frank,
van den Berg Eva,
Dhooge Catharina,
Oosterhuis Wolter,
Redeker Bert,
De Potter Christian R.,
Tamminga Rienk Y. J.,
Van Roy Nadine,
Mannens Marcel
Publication year - 1998
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/(sici)1098-2264(199803)21:3<265::aid-gcc13>3.0.co;2-o
Subject(s) - loss of heterozygosity , isochromosome , biology , genetics , gene duplication , chromosome , wilms' tumor , karyotype , trisomy , abnormality , gene , allele , medicine , psychiatry
Cytogenetic and molecular analyses were performed on three cellular (atypical) congenital mesoblastic nephromas (CMNs). Two cases had trisomy 11; in one, it was the sole karyotypic abnormality, and the other had additional numerical changes as well as an isochromosome for the long arm of chromosome 1. Markers for the 11p13 and 11p15 loci were present in three copies in these two CMNs. In the third CMN, two apparently normal copies of chromosome 11 were present together with additional numerical and structural chromosome changes. Because loss of heterozygosity was observed for both 11p13 and 11p15 markers, we assume that mitotic recombination occurred. Duplication and loss of imprinting of genes at 11p15 has also been observed frequently in Wilms' tumor. We therefore propose that CMN and Wilms' tumor might share common genetic pathways. Genes Chromosomes Cancer 21:265–269, 1998. © 1998 Wiley‐Liss, Inc.