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Follicular thyroid carcinoma: Chromosome analysis of 19 cases
Author(s) -
Roque Lúcia,
Clode Ana,
Belge Gazanfer,
Pinto António,
Bartnitzke Sabine,
Santos Jorge Rosa,
Thode Brita,
Bullerdiek Jörn,
Castedo Sérgio,
Soares Jorge
Publication year - 1998
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/(sici)1098-2264(199803)21:3<250::aid-gcc10>3.0.co;2-t
Subject(s) - karyotype , follicular phase , thyroid , monosomy , pathology , biology , chromosome , thyroid carcinoma , chromosome abnormality , chromosome 7 (human) , cytogenetics , carcinoma , cancer research , medicine , genetics , gene
Short‐term cultures of 19 follicular thyroid carcinomas were examined cytogenetically. Clonal chromosomal changes were detected in 12 tumors. Two follicular carcinomas had only numerical alterations: one with a hyperdiploid karyotype with trisomies/polysomies of chromosomes 7 and 12, similar to the karyotypes previously identified in a sub‐group of benign thyroid lesions, and the other with monosomy 20. In the remaining ten cases several structural chromosome anomalies were found. Loss of the short arm of chromosome 3 was observed in one tumor. In two widely invasive and metastasizing follicular carcinomas there was a t(7;8)(p15;q24) as the sole abnormality in one case and a der(8)t(7;8)(p15;q24) together with other cytogenetic alterations in the other case. This finding suggests that t(7;8)(p15;q24) may be related to an aggressive behavior of follicular thyroid carcinomas. Genes Chromosomes Cancer 21:250–255, 1998. © 1998 Wiley‐Liss, Inc.